TNF and chronic kidney disease: The central components of LWDH, including quercetin, stigmasterol, kaempferol, beta-sitosterol, tetrahydroalstonine, kadsurenone, hederagenin, hancinone C, diosgenin, and sitosterol, play a vital role in regulating the response to chemical stimuli, reactive oxygen species metabolism, and key signaling pathways such as AGE-RAGE, IL-17, and TNF pathways for CKD.