NT-proBNP, coexisting in circulation with BNP in 1 to 1, is easy to be determined because of its longer half-life (3 to 4 times longer than BNP), higher quantity (16 to 20-fold higher than BNP), and more stable concentration in the blood, which makes NT-proBNP concentrations relatively more stable than BNP over brief time periods.[26] Thus, plasma NT-proBNP level as a cardiac biomarker may be an interesting alternative to BNP.[27] Based on 25 related studies, our meta-analysis shows that the AF recurrence group had a significantly higher pre-ablation level of NT-proBNP. This evidence concerns the gene NPPB and atrial fibrillation.