SYNE2 and Emery-Dreifuss muscular dystrophy: In human keratinocytes, nesprin-2 was shown to have a role in Ca2+/calmodulin mediated nuclear trafficking, and displacing nesprin-2 from the NE results in elevated cytoplasmic Ca2+ levels, caused by a mutation (T6211M) in the C-terminus of nesprin-2, identified in familial EDMD-conduction defects [112].