Although previous studies have shown that fibroblast recruitment is essential for tumor development and that sEVs from PDAC cells can promote PSC recruitment by activating the Lin28B/let‐7/HMGA2/PDGFB signaling pathway [31, 68, 69], further studies are needed to elucidate the mechanisms by which PDAC cell‐derived sEVs recruit fibroblasts to the tumor. The gene discussed is HMGA2; the disease is neoplasm.