As an endogenous TLR7 ligand, miR‐1983 activates TLR7 in pDC and cDC via the 5′‐UGUUU‐3′ motif at its 3′ end and further activates downstream signaling, stimulating IFN‐β secretion via MyD88‐IRF5/IRF7, and ultimately eradicating gliomas through stimulation of NK cells.114. This evidence concerns the gene TLR7 and central nervous system cancer.