Several genes associated with wool traits showed clear evidence of positive selection, including notch receptor 2 (NOTCH2) in ZK and GY, Rho associated coiled-coil containing protein kinase 1 (ROCK1) in GY, fibroblast growth factor 5 (FGF5) in GY and HZ, and SOX9 in BD and OL. This evidence concerns the gene NOTCH2 and Behcet disease.