In pan-cancer analysis, SHOX2 expression positive correlated with CDKN2C (R = 0.41), COL6A1 (R = 0.35), COL6A2 (R = 0.37), DCHS1 (R = 0.37), MAPK7 (R = 0.34), PRRX1 (R = 0.37), RAB23 (R = 0.36) and RSRC1 (R = 0.36) via GEPIA2 (Fig. 3B). This evidence concerns the gene PRRX1 and cancer.