We acquired the top 8 genes that positively related to SHOX2 expression by the GEPIA2 portal and these top 8 genes, including CDKN2C, COL6A1, COL6A2, DCHS1, MAPK7, PRRX1, RAB23 and RSRC1, were drawn into heatmap in pan-cancers via TIMER2 (Fig. 3A). This evidence concerns the gene MAPK7 and cancer.