It has been reported that HSPB7 is the most potent molecular chaperone among the sHSP family in suppressing the aggregation of polyglutamine-containing proteins, which cause neurodegenerative conditions including Huntington’s disease and Kennedy’s disease [30], and most importantly, this anti-aggregation function is conserved among species [43]. The gene discussed is HSPB7; the disease is juvenile Huntington disease.