A large number of studies have confirmed that there is abnormally glycosylated IgA1 (galactose deficient IgA1, Gd-IgA1) in the serum and urine of IgAN patients, which is significantly higher than that of other glomerular diseases, such as nephrotic syndrome, lupus nephritis and other patients and healthy controls crowds [4, 5]. This evidence concerns the gene IGHA1 and nephrotic syndrome.