In the process, platelet-secreted chemokines (like CXCL5 and CXCL7) [88], growth factors (like VEGF, PDGF, and TGF-β)[89], and PMPs-derived miRNA [90] support the proliferation, formation of pre-metastatic nitch and seeding of metastatic tumor cells. The gene discussed is VEGFA; the disease is neoplasm.