VWF and neoplasm: Numerous studies have investigated the targeting direct molecule contacts, including platelet GPIIb-IIIa (also called αIIbβ3 integrin)-plasma fibrinogen or fibronectin - tumor αVβ3 integrin [19–21]; platelet GPIbα - tumor Von Willebrand Factor (vWF) [22–24]; platelet GPVI - tumor fibrin and/or subendothelial collagen [25, 26]; platelet α6β1 integrin-tumor ADAM9 [27]; platelet acid sphingomyelinase (Asm) – tumor α6β1 integrin [28, 29]; platelet CLEC-2-tumor podoplanin [30–32]; and platelet P-selectin-tumor P-selectin ligand [33–35].