In this study, when PCa cells were stimulated with high levels of FFA C8:0 and GPR84 antagonist 8, the proliferation, colony formation, invasion, and migration capabilities enhanced by FFA C8:0 were significantly weakened, and the enhanced mRNA and protein expression levels of KLF7/IL-6 were significantly reduced, while the expression level of p21 was reversed. Here, GPR84 is linked to posterior cortical atrophy.