Because four genes (YTHDC1,YTHDF1-3) in m6A and m1A were duplicated, and there were no expression profile data of NSUN1 and DNMT2 for the TCGA database, we used the Wilcoxon test to analyze the differential expression of 42 m6A/m5C/m1A regulator genes from 374 HCC tissues and 50 normal tissues. The gene discussed is YTHDC1; the disease is hepatocellular carcinoma.