IGF2 and Beckwith-Wiedemann syndrome: Having demonstrated trends for hypomethylation in ICRs of imprinted genes, and sex-specific effects, we were interested in examining, in greater detail, the ICRs for two imprinted genes for which disruptions in DNA methylation account for the majority of Beckwith-Wiedemann syndrome cases in the ART-conceived population: KCNQ1OT1 and H19/IGF2 ICRs [15].