The silencing of USP3 resulted in distinct morphological changes in SH-SY5Y, SK-N-SH and SK-N-DZ neuroblastoma cell lines, exhibiting a flatter and differentiated cell appearance with neurite-like processes compared to the scrambled-shRNA transfected neuroblastoma cells (Fig. 6E F and Supplementary Fig. 9 and 10 A-10B). This evidence concerns the gene USP3 and neuroblastoma.