USP3 and neuroblastoma: However, USP3-depleted neuroblastoma cells, when reconstituted with USP3, resulted in an increase in the number and size of the neurospheres (Fig. 5C and D and Supplementary Fig. 7B–7C) and were rescued from any morphological abnormalities in the neurospheres (Fig. 5E and Supplementary Fig. 7D).