PGR and breast cancer: Per HLS increment of 1 point, the HR for overall breast cancer was 0.80 (95%CI, 0.74, 0.87), while the HRs for the subtypes ranged from 0.71 (95%CI, 0.60, 0.85) for ER + PR- to 0.86 (95%CI, 0.72, 1.03) for ER- breast cancer (Table 3).