Several miRNAs have been causally linked to CLL pathogenesis, including miR-15a/16-1, miR-29b/miR-181b, miR-181b and miR-34a that interact with the anti-apoptotic and cell cycle control genes BCL2, TCL1, MCL1 and TP53 respectively [16–19]. This evidence concerns the gene MCL1 and B-cell chronic lymphocytic leukemia.