MEG3 and B-cell chronic lymphocytic leukemia: However, in our data we did not observe significant differential methylation of the MEG3 gene body, MEG3 promoter, the MEG3-DMR or the IG-DMR (although the IG-DMR was poorly covered by the array) amongst our CLL subgroups, and we did not identify substantial variation in methylation levels in this locus amongst the cohort (Fig. S10).