Aberrant DMR methylation is observed in several leukaemias, including hypermethylation of the MEG3-DMR in AML, MDS and myeloma [41, 58], and loss of IG-DMR imprinting is associated with increased MEG3 and 14q32 miRNA expression in acute promyelocytic leukaemia [59]. The gene discussed is MEG3; the disease is myelodysplastic syndrome.