GAB1 and B-cell chronic lymphocytic leukemia: Our data illustrates the critical role of miRNA-mediated regulation in the pathobiology of CLL, showing that the 14q32 miRNA have a putative regulatory role in IGHV-associated transcription, with functional evidence of a mechanistic interaction with GAB1. Given that these naturally produced molecules and their levels can be readily regulated with miRNA mimics or miRNA/antagomiRs, their therapeutic manipulation may have implications for more effective deployment of existing targeted agents.