Therefore, in addition to the previously reported ability of miR-150-5p to reduce GAB1 expression in CLL cells [21], we now show that two further miRNA, miR-411-3p and miR-409-3p, located at 14q32 also regulate GAB1 and associate with IGHV and BCR signalling status. This evidence concerns the gene GAB1 and B-cell chronic lymphocytic leukemia.