A common set of proteins including B-Raf, A-Raf, C-Raf, AKT, mTOR, p38-MAPK, and Erk5, which are associated with tumor growth and proliferation were upregulated in osimertinib treated NCI-H1975-OsiR tumors (Fig. 3f, right; Suppl Fig. 3c). The gene discussed is RAF1; the disease is neoplasm.