By considering KEGG enrichment (Fig. 6) and examining the pathways of bacterial infections in humans, it was found that bordetella pertussis infection by association with human proteins (CXCL5, CXCL6, IL6, IL1B, IL1A) and staphylococcus aureus infection by association with 2 human proteins (ICAM1, SELP) affect inflammatory reactions in the human host (Fig. 7). Here, CXCL6 is linked to bacterial infectious disease.