By considering KEGG enrichment (Fig. 6) and examining the pathways of bacterial infections in humans, it was found that bordetella pertussis infection by association with human proteins (CXCL5, CXCL6, IL6, IL1B, IL1A) and staphylococcus aureus infection by association with 2 human proteins (ICAM1, SELP) affect inflammatory reactions in the human host (Fig. 7). The gene discussed is ICAM1; the disease is bacterial infectious disease.