We also predicted the most effective cores for siRNAs to affect staphylococcus aureus (ClfB, IsdA, sdrC, sdrD, and SasG) and pertussis (PtxE, PagP, PtxD, PtxC, PtxA, and PtxB) bacterial genes that interacted with human KRT10, FGG, and TLR4 genes. This evidence concerns the gene KRT10 and pertussis.