Nonetheless, we are not aware that allelic level should be the final goal for HLA studies, as in many diseases that initially were associated with an antigen (allele group level) that with further studies have pointed out that only some alleles of the group were in association with the disease, as for spondyloarthropathies with HLA-B*2752 or rheumatic arthritis HLA-DRB*0453. The gene discussed is HLA-DRB1; the disease is spondyloarthropathy.