After univariate and multivariate analysis, alleles HLA-A*68 and -C*07 showed a higher frequency in the HAM/TSP group than in the AC group, even after being adjusted by age, gender, ethnicity, and time of clinical follow-up (Table 2, OR 2.03 (1.19–3.46, 95% CI), p = 0.01, and OR 1.61 (1.04–2.48, 95% CI), p = 0.03, respectively), and were associated to HAM/TSP risk. Here, HLA-A is linked to tropical spastic paraparesis.