ALB and Hepatic steatosis: Hematoxylin and eosin (H&E) and oil red O (ORO) staining revealed that the hepatic steatosis and lipid accumulation were not altered in CD-HFD-fed Ugdhf/f;Alb-Cre mice compared with that of CD-HFD-fed Ugdhf/f mice (Supplementary Fig. 2f), which was further confirmed by measuring hepatic concentrations of triglycerides (TG), total cholesterol (TC) and nonesterified fatty acids (NEFA) (Supplementary Fig. 2g).