RIPK1 and steatosis: Inactivating RIPK1 in Ugdhf/f;Alb-Cre;Ripk1D138N/D138N mice did not affect body weight and liver weight after feeding CD-HFD (Supplementary Fig. 4b), nor did it affect hepatic steatosis and lipid accumulation as determined by H&E and ORO staining, as well as hepatic TG, TC and NEFA measurement (Supplementary Fig. 4c–e).