All members within the MMPs family are precursor enzymes that require proteolysis to be effective, including collagenases, gelatinases, stromelysins, matrilysins, and MMP membrane-type (MT)-MMPs.322 The major subunits involved in tumor angiogenesis are MMP-2, MMP-9 and MMP-14.323 MMP-2 is a 72 kDa gelatinase A or type IV collagenase that degrades types I and IV collagen. This evidence concerns the gene MMP9 and neoplasm.