EPHA3 and malignant colon neoplasm: For example, EphrinB2 is over-expressed in ovarian cancer, kidney cancer and melanoma, whereas EphrinA3 is up-regulated in squamous cell lung carcinoma (SCLC) and colon cancer.296 As for receptor subunits, EphB3, EphB4 and EphB6 are excessively activated in colon cancer, but EphA2, EphA3, EphA4, EphA6, and EphA7 are expressed at a high level in lung cancer.296