At the same time, it can neutralize excess VEGF, reconstruct the vascular system of tumor tissue, normalize vascular network, promote the blood transport of immunosuppressant, inhibit excessive angiogenesis, reduce microvascular density, and limit tumor growth, invasion and metastasis.529 Additionally, ICIs activate intratumoral effector T cells, reshape the TME, improve immunity of host, and up-regulate expression of γ-interferon,529 all of which are conducive to vascular normalization. The gene discussed is VEGFA; the disease is neoplasm.