For instance, endostatin is an enzymatic fragment of XVIII collagen with a molecular weight of about 20 kDa that was identified by O’ Reilly and his colleagues in 1997.546 Endostatin can not only regulate more than 12% of angiogenesis-related genes in the human genome but can also compete with FGFs to limit ECs proliferation and tumor development. This evidence concerns the gene COL18A1 and neoplasm.