In addition to TERT, BLCAP, and KBTBD8, we also observed low levels of damage induction in UV-irradiated melanocytes at a number of other recurrent mutations in the promoters of known or suspected cancer genes (i.e., TCF3, TOP2A, NUMB, FOSB, and OTUB2; Fig. 4a). Here, OTUB2 is linked to cancer.