Alcoholic liver disease is the major cause of liver disorders, widely risking the health of heavy drinkers.152 The engineered Bacillus subtilis and L. lactis could be employed to express ethanol degradation pathway (alcohol dehydrogenase and aldehyde dehydrogenase) for the detoxification of alcohol and alleviate liver injury from alcohol overconsumption.153 Moreover, the lectin regenerating islet-derived 3 gamma (REG3G) protein is decreased in the gastrointestinal tract during chronic ethanol uptake. This evidence concerns the gene REG3G and alcoholic liver diseases.