Indeed, this drug mimics the tumor suppressor function of p140Cap on the epistatic β-Catenin/TIC/G-CSF/PMN-MDSCs axis, recapitulating in its entirety both the effects of p140Cap at the primary tumor site (shrinkage of the TIC compartment and inhibition of tumorigenicity) and its tumor-extrinsic effects at the local and systemic level (reduced secretion of G-CSF and impaired PMN-MDSCs systemic mobilization and local TME infiltration). The gene discussed is CSF3; the disease is neoplasm.