SRCIN1 and neoplasm: These results are of the utmost relevance to a deeper understanding of the function of p140Cap as a tumor suppressor, considering the emerging liaison between TME anti-tumor immune response and negative control of tumor progression and metastasis68 and, conversely, the close association between an immunosuppressive TME, with presence of MDSCs, Tregs and M2-polarized macrophages, and enhanced tumor progression69–71.