Collectively, the sum of our biochemical and imaging studies highlights a tumor suppressor function of p140Cap as a direct negative regulator of β-Catenin, revealing that the stabilization of the β-Catenin destruction machinery represents the bona fide mechanistic site of action for the p140Cap-mediated inhibition of the epistatic β-Catenin/TIC/G-CSF/PMN-MDSCs axis. Here, CSF3 is linked to neoplasm.