To address whether p140Cap could influence G-CSF secretion through regulation of the TIC compartment, we initially analyzed the consequences of p140Cap expression on the mammosphere-forming potential of TuBo and 4T1 cells, including in these studies the human BC cell line, MDA-MB-231, as a model of poorly differentiated TNBC BC with basally low p140Cap levels. The gene discussed is CSF3; the disease is breast cancer.