Prompted by the above clinical observations, we investigated the involvement of p140Cap in influencing the immune infiltrate and inflammatory responses in the TME, by exploiting two syngeneic mouse models for human BC: (i) the TuBo cells, an established cell line from BALB/c-MMTV-NeuT mice, a model for HER2+ BC35; (ii) the highly tumorigenic and invasive murine mammary carcinoma cell line 4T1, a model for stage IV TNBC36. This evidence concerns the gene SRCIN1 and breast carcinoma.