At the molecular level, there are 5 major subtypes of bladder cancer, including luminal (HER2/3 high, papillary) (Cancer Genome Atlas Research, 2014), HER2-expressing, and basal (squamous cell, mesenchymal cell) (Hedegaard et al., 2016; Choi et al., 2014; Kamoun et al., 2020). This evidence concerns the gene ERBB2 and urinary bladder cancer.