A set of genes that overlapped between the marker genes of the Irf6+ epithelial subsets and CL/P candidate genes was identified (Table 1), which included CL/P genes that were associated with: (i) syndromic forms (e.g., Tfap2a (Branchio-oculo-facial syndrome, Milunsky et al., 2008), Ctnnd1 (Blepharocheilodontic syndrome 2, Ghoumid et al., 2017) and Fras1 (Fraser syndrome 1, Fraser, 1962); and (ii) candidate genes from GWAS loci (e.g., Tpm1 (Ludwig et al., 2012) and Arid3b (Leslie et al., 2017) (Table 1, Supplementary Table S4). The gene discussed is FRAS1; the disease is Blepharo-cheilo-odontic syndrome.