A set of genes that overlapped between the marker genes of the Irf6+ epithelial subsets and CL/P candidate genes was identified (Table 1), which included CL/P genes that were associated with: (i) syndromic forms (e.g., Tfap2a (Branchio-oculo-facial syndrome, Milunsky et al., 2008), Ctnnd1 (Blepharocheilodontic syndrome 2, Ghoumid et al., 2017) and Fras1 (Fraser syndrome 1, Fraser, 1962); and (ii) candidate genes from GWAS loci (e.g., Tpm1 (Ludwig et al., 2012) and Arid3b (Leslie et al., 2017) (Table 1, Supplementary Table S4). This evidence concerns the gene ARID3B and Blepharo-cheilo-odontic syndrome.