Mouratidis et al. (2015) demonstrated that RIPK3 protein levels of human colon cancer cells were increased after thermal exposure. This suggests that heat therapy and drugs targeting hypoxia may synergize with necroptosis as an applicable therapy for future cancer treatment. We concluded the role of necroptosis in tumor progression and cancer treatment in Figure 11. The gene discussed is RIPK3; the disease is colonic neoplasm.