To examine the role of PEITC in the proliferation of ESCC cells with different p53 statuses, we treated the human ESCC cell lines KYSE150 (p53R248Q) (p53 gene mutation information from COSMIC database and Supplementary Figure S1) and EC109 (WT p53) with PEITC. The gene discussed is TP53; the disease is esophageal squamous cell carcinoma.