TP53 and esophageal squamous cell carcinoma: Although PEITC can selectively and preferentially act on ESCC cells expressing mutp53, we also observed that PEITC is able to inhibit proliferation and induce apoptosis in wtp53 ESCC cells, which may be attributed to p53-dependent induction of apoptosis by PEITC in wtp53 cells (Huang et al., 1998).