TP53 and neoplasm: Significantly higher protein levels of the classic p53 target genes p21, BAX, and PUMA, as well as increased levels of the Bcl2 protein, were detected in the KYSE150 xenograft-tumor-bearing mice treated with PEITC than in the mice in the DMSO control group (Figure 6C); similar phenomena were not observed in the xenograft-tumor-bearing mice with the remaining three esophageal squamous carcinoma cells (Figure 6C).