Exosomal circLPAR1 and methyltransferase-like 3 (METTL3) competitively bind RBP eIF3h, effectively reducing the translation of brominated protein 4 (BRD4) and subsequently inhibiting the proliferation, invasion, and migration of colorectal cancer cells (Zheng et al., 2022). This evidence concerns the gene METTL3 and colorectal cancer.