GPX4 and hepatocellular carcinoma: Moreover, the authors further experimentally demonstrated that downregulating miR-541-3p alleviates the inhibition of tumorigenesis and promotion of ferroptosis caused by circIL4R knockdown, and inhibiting circIL4R reduces GPX4 by upregulating miR-541-3p to prevent tumor cell proliferation and inhibit HCC tumor progression, thereby hindering HCC growth and metastasis in vivo.