Other ncRNAs involved in oxidative stress and inflammation-related disorders are circular RNAs such as circ-PRKCA, circ-ZNF83, circ-PLEKHM3, circ-FNDC3B, circ-102115 circSATB2 and circFOXM1 on which natural products modulation have been investigated on in cancers and other chronic diseases (Zhang H. et al., 2022). The gene discussed is PLEKHM3; the disease is cancer.