Moderate weight of evidence supporting induction of primary hepatic steatosis in vitro (including mechanistic support and transcriptomic/metabolomic data). Moderate-weak, but not contradicting weight of evidence in vivo (rodent and human). Strong weight of evidence supporting induction of steatosis in Amphibians in vivo, although human relevance and predictivity is uncertain (e.g., due to substantial species-specific structural differences in PPARγ ligand binding pocket). The gene discussed is PPARG; the disease is Hepatic steatosis.