ERVW-1 and infection: In another study, mRNA-LNP vaccine encoding HIV-1 Env and simian immunodeficiency virus (SIV) Gag proteins to generate virus-like particles, induced broad neutralising antibodies and reduced the risk of infection in rhesus macaques immunized through a prime-boosts protocol with autologous and mixed heterologous Env challenged with repeated low doses of heterologous SHIV (127).