To determine the biomarker reliability of the inflammasome signaling proteins caspase-1 (Figure 2A), ASC (Figure 2B), IL-1β (Figure 2C) and IL-18 (Figure 2D), we plotted ROC curves for each protein using data from healthy subjects and from patients that tested positive for COVID-19 and presented an active infection (Figure 2). The gene discussed is CASP1; the disease is infection.