Additionally, TDP-43 pathology-related cryptic exon RNAs translated protein product have been observed in induced pluripotent stem cells derived neurons with TDP-43 deficiency as well as in CSF from FTD-ALS patients; this may represent a viable target for peptide-based biomarker development (Ling et al., 2015; Seddighi, 2023). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.