IGHE and allergic rhinitis: Degranulationfollowing entry of an allergen to immunoglobulin E (IgE)‐sensitizes mast cells that causes the release of histamine which is responsible for the symptoms of allergicrhinitis.Since decades, first generation antihistaminic drugs have been used in the management of allergic rhinitis, but because of lipophilic in nature it readily crossesblood brain barrier leading to central nervous system side effects such as sedation, and drowsiness that affects the routine life of the society.