LCN2 and multiple sclerosis: On the other hand, LCN2 has also been described with important roles in the diseased brain, particularly in mild cognitive impairment (Choi et al., 2011), Alzheimer’s disease (Naude et al., 2012), multiple sclerosis (Marques et al., 2012) and, more recently, in Parkinson’s disease (Kim et al., 2016).