On the other hand, LCN2 has also been described with important roles in the diseased brain, particularly in mild cognitive impairment (Choi et al., 2011), Alzheimer’s disease (Naude et al., 2012), multiple sclerosis (Marques et al., 2012) and, more recently, in Parkinson’s disease (Kim et al., 2016). This evidence concerns the gene LCN2 and early-onset autosomal dominant Alzheimer disease.