Using online RNA‐sequencing (RNA‐seq) data from GEPIA (Gene Expression Profiling Interactive Analysis) database (http://gepia.cancer‐pku.cn/), we found TXNL4B expression levels elevated in most of the cancers, including COAD (colon adenocarcinoma), ESCA (esophageal carcinoma), LUSC, PAAD (adenocarcinoma of the pancreas), SARC (sarcoma), STAD (stomach adenocarcinoma) compared with the corresponding adjacent normal tissues (Figure 2A). The gene discussed is TXNL4B; the disease is cancer.