As shown in Figure 5D, the 3D structure of TXNL4B and PRP3 can bind together potential, as well as PRP3 plays essential roles in the spliceosome pre‐mRNA splicing (Figure 5E), whether PRP3 is involved in the regulation of alternative splicing in lung cancer cells postradiation needed to be evaluated. This evidence concerns the gene PRPF3 and lung cancer.