CRLF3 and amyotrophic lateral sclerosis: Moreover, CRLF3 levels have been detected in tumors and various tumor cell lines (Dang et al., 2006; Yang et al., 2009) and sequence alterations have been linked to amyotrophic lateral sclerosis (ALS; Cirulli et al., 2015), autism spectrum disorders (Wegscheid et al., 2021) and sensitivity to Leishmania infections (Castellucci et al., 2021).