CRLF3 has been associated with a variety of diseases including neurofibromatosis type I, cutaneous Leishmaniasis, cutaneous squamous cell carcinoma, amyotrophic lateral sclerosis, autism and cancer (Dang et al., 2006; Serra et al., 2019; Castellucci et al., 2021; Kehrer-Sawatzki et al., 2021; Wegscheid et al., 2021). Here, CRLF3 is linked to cutaneous squamous cell carcinoma.