DCTN1 protein mutants, including T1249I, M571T, R785W, and R1101K, have been reported as possible risk factors for ALS (Münch et al., 2004; Mäki-Marttunen et al., 2020); however, further studies are needed to determine their specific roles in the disease. Here, DCTN1 is linked to amyotrophic lateral sclerosis.