The specific mechanism by which axonal transport defects are involved in the pathogenesis of ALS is unclear and may involve several processes, including the mutation of genes encoding axonal transport-related proteins (Puls et al., 2003), altered microtubule stability (Godena et al., 2014), the hyperphosphorylation of motor proteins (Morfini et al., 2013), and weakening of associations between cargoes and motor proteins (Ackerley et al., 2003). Here, IMMT is linked to amyotrophic lateral sclerosis.