An additional larger GWAS including 11 population-based cohort studies and 3 case–control or case-only stroke cohorts found one locus in the APOE region reaching genome-wide significance (rs769449; OR 1.33 95% CI 1.21–1.45) for any CMB, while APOE ε4 alleles were associated with strictly lobar CMB (OR 1.34, 95% CI 1.19–1.50) but not with mixed CMB. The gene discussed is APOE; the disease is stroke disorder.