But as a corollary for a compensatory role of enhanced T-cell function during B cell therapy, anti-COVID vaccinations in MS induce (1) flu-like symptoms from release of type I IFNs, lymphotoxin, and TNF-α and cytokines from myeloid cells (41, 53), (2) a rise in CD8+ cytolytic T cells, (3) clear CD8 and CD4 T-cell responses to COVID antigens (49, 54), (4) a fourfold increase in IFN-γ-secreting T cells (55), and (5) effective T-cell responses after a third booster vaccination (56). This evidence concerns the gene CD4 and myeloid sarcoma.