CD163 and peeling skin syndrome: Interestingly, a histological study of lip SGs from pSS patients showed that the number of CXCR3+/CD163+ M2 macrophages was inversely correlated with the severity of inflammatory lesions, demonstrating that M2 macrophages play an anti-inflammatory role in pSS lesions (Aota et al., 2018; Ushio et al., 2018).