In cells, the expression of P57 and NSUN2 were negatively correlated, and the high expression of NSUN2 reduced the stability of mRNA, inhibited the expression of P57, and promoted the proliferation of tumor cells by catalyzing m5C methylation in the 3′UTR region of P57 mRNA (Mei et al., 2020). This evidence concerns the gene NSUN2 and neoplasm.