With more than 2,100 disease-associated variants reported in CFTR (Sosnay et al., 2013; The Clinical and Functional TRanslation of CFTR CFTR2, 2021; Cystic Fibrosis Mutation Database, 2022), these variants are categorized by molecular attributes such as little-to-no transcript and/or polypeptide production, decreased protein maturation, or impaired channel gating (Oliver et al., 2017; Ensinck and Carlon, 2022) (Figure 1). Here, CFTR is linked to cystic fibrosis.