Since PV neurons (especially PV basket cells) play an essential role in synchronizing action potentials within the neuronal population during working memory tasks (γ-oscillations; Gonzalez-Burgos and Lewis, 2008; Gonzalez-Burgos et al., 2010), GAD67 reduction is hypothesized to be the origin of cognitive impairment in schizophrenia. The gene discussed is GAD1; the disease is schizophrenia.