IL6 and neoplasm: These stimuli can be CAF-derived exosomes with miscellaneous content including TGF-β (30), long non-coding RNAs (lncRNAs) (41), and Snail1 transcription factor, which is characterized by facilitating tumor metastasis and promoting tumor drug resistance and recurrence (42), as well as soluble secreted interleukin 6 (IL-6) (43).