CDH5 and metastatic malignant neoplasm in the lymph nodes: Various subtypes of CAFs associated with the progression of this neoplasm have been reported; periostin-positive CAFs are involved in lymph node metastasis and with poor survival of CC patients due to the promotion of the permeability of lymphatic endothelial barriers through activation of integrin-FAK/Src-VE-cadherin signaling pathway in lymphatic endothelial cells, which decreases the expression of VE‐cadherin favoring metastatic dissemination (163).