ACTA1 and neoplasm: In pancreatic ductal adenocarcinoma, they subdivide them into two main populations characterized by their location and functionality: activated CAFs close to the tumor with a myofibroblast phenotype (myCAF) express high levels of α-SMA and low levels of cytokines, whereas inflammatory CAFs (iCAFs) far from the tumor express low levels of α-SMA and high levels of cytokines (92).