NPPB and ovarian cancer: The difficulty of diagnosing ovarian cancer in its early stages is mainly due to the anatomical site where the ovaries are located and the lack of early biomarkers; in search of new candidates for biomarkers, Lawrenson et al., have non-invasively detected natriuretic peptide B (NPPB), a hormone initially unrelated to ovarian neoplasia and that is secreted from cardiac ventricular myocytes in response to myocardial stretch and stress, in the stroma of 60% primary OC tissues and the blood of 50% of women with OC (129).