Extracellular matrix (ECM) remodeling is one of the characteristics of CAFs, this mainly proteolytic event facilitates the invasion and metastasis of tumor cells; some of the proteins secreted by CAFs are enzymes such as MMP11, which is a metalloproteinase belonging to the endoproteases family, responsible for the degradation of the ECM (59). This evidence concerns the gene MMP11 and neoplasm.