PDGF-BB secreted by cancer cells induces the expression of heparin-binding epidermal growth factor-like growth factor (HB-EGF) by CAFs, through activation of PDGFRβ, which in turn activates epidermal growth factor receptor (EGFR) in CC cells promoting cell proliferation and tumor growth, in in vitro and in vivo models, respectively. Here, HBEGF is linked to neoplasm.