In addition, grade 3-4 non-hematological adverse events were elevated GGT (14.3%), diarrhea (10.8%), elevated bilirubin (7.1%), elevated alanine aminotransferase (ALT) (3.5%), elevated aspartate aminotransferase (AST) (3.5%), hypertension (3.5%), and hand-foot syndrome (3.5%) (Table 5). This evidence concerns the gene GPT and Hand-foot syndrome.