ERBB2 and neoplasm: According to the guidelines recommended by the Chinese Society of Clinical Oncology, the first-line systematic therapy for advanced GAC and GEJA is fluorouracil-based chemotherapy plus immunotherapy (combined with trastuzumab if the tumor presents human epidermal growth factor receptor 2 (HER2)-positive), while the second-line therapy is limited and merely includes paclitaxel, docetaxel, and irinotecan monotherapy or their combination, as well as paclitaxel and ramucirumab combination (9, 10).