HMGB1 and neoplasm: At the same time, SDT also generates a series of adjuvant-like signaling molecules, namely DAMPs, including calreticulin (CRT) exposed on the cell surface, high mobility group protein 1 (HMGB1) secreted out tumor cells, adenosine triphosphate (ATP) and heat shock proteins (HSP70, HSP90) released by cells.