In this study, bioinformatics analysis based on the TCGA database was performed to analyze the correlation between CCNF expression level and survival, sex, race, clinicopathological stage, tumor mutation burden (TMB), microsatellite instability (MSI) status, DNA methylation level, single nucleotide variation (SNV), copy number variation (CNV), immune cell infiltration, immune matrix score and immune checkpoint gene expression across cancers. This evidence concerns the gene CCNF and cancer.