miR-34a-5p is targeting large number of genes playing important role in cancer development including MYC, MET, cell-cycle related genes CCND1 (cyclin D1), WNT1, MAP2K1, NANOG, TP53, SRC and AKT1 to target mTOR signaling pathway, Wnt signaling pathway, MAPK signaling pathway, p53 signaling pathway among additional crucial pathways, which play crucial role in HCC tumorigenesis, tumor growth and angiogenesis (62). This evidence concerns the gene CCND1 and hepatocellular carcinoma.