The downstream target of HOTAIR, Flotillin 1 (FLOT1), a crucial tumor gene that is connected to the invasion and metastasis of malignancies and can be employed as a stable scaffold when enlisting multi-protein complexes (75), makes the HOTAIR/miR-214-3p/FLOT1 an important axis of how HCC invades and spreads (72). This evidence concerns the gene HOTAIR and hepatocellular carcinoma.