(87) find that miR-130a-3p was significantly decreased in cirrhosis but when miR-130a-3p was injected into the liver effectively decreased liver granulomatous inflammation, decreased expression of the tissue inhibitor of metalloproteinase (TIMP), collagen deposition, and increased the expression of matrix metalloproteinase (MMP) which contributed to the dissolution of collagen (87). Here, TIMP1 is linked to digestive system neoplasm.